Why is uric acid elimination sometimes insufficient? Besides certain diets, there are a number of other reasons and one of them is the inherited dysfunction of a protein pump known as ABCG2. When too much uric acid is produced however, it precipitates as urate crystals that slowly build up finally causing excruciating pain - surprisingly at the base of the big toe in about half of gout cases. Uric acid comes from the breakdown of purine we ingest from the food we eat, and is usually processed by our kidneys and then eliminated with our urine. Gout is an inflammation caused by the accumulation of needle-like crystals of uric acid deposited in joints, tendons or their surrounding tissues. However, as the excessive indulgence in over-rich foods has spread across a great part of the world, gout too has spread - and not only on a geographical scale but also throughout the various strata of human society. Throughout history, this particular form of arthrosis has been associated with the exaggerated consumption of rich foods and excessive alcohol, and consequently described as "arthritis of the rich" since, in the early days, only the higher classes of society seemed to suffer from it. This intentionally creates transitory therapeutic petechiae called ‘Sha’. Pain is aggravated by lifting and movement, and relieved by rest. Not too much of this, not too little of that. Hippocrates's Unwalkable Disease Supraspinatus Tendon Case Study. Why is uric acid elimination sometimes insufficient? Besides certain diets, there are a number of other reasons and one of them is the inherited dysfunction of a protein pump known as ABCG2.Health is really all a question of balance. First identified by the Egyptians in 2640 BC 1, podagra (acute gout occurring in the first metatarsophalangeal joint) was later recognized by Hippocrates in the fifth century BC, who referred to it as 'the unwalkable disease'. The reasoning behind ‘gout’ being associated with such terms lies in the inherent nature of gout as a disease and its causative factors. The first to call the disease ‘gout’ from the Latin ‘gutta’ meaning ‘drop’ was the Dominican monk Randolphus of Bocking in the 13th century when scholars still believed that health and temperament depended on a balance between four main bodily fluids or humors. Gouty arthritis was among the earliest diseases to be recognized as a clinical entity. When too much uric acid is produced however, it precipitates as urate crystals that slowly build up finally causing excruciating pain - surprisingly at the base of the big toe in about half of gout cases. In ancient times of 5th century, Hippocrates regarded as the father of medicine described gout as the the unwalkable disease. Not too much of this, not too little of that. In fact, it was one of the first diseases to be recognized in humans by the early Egyptians in 2640 BC. Health is really all a question of balance. Gout has been an issue for human beings for thousands of years.
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